Comext Supply Wholesale Spermidine Powder Spermidine Trihydrochloride

• Certification: ISO, FDA, HACCP
• Assay Method: HPLC
• Application Form: Paste, Tablet, Capsule
• Application: Food, Health Care Products
• State: Powder
• Extract Source: Chemicals
• Model NO.: SPER-2
• Color: White to off-White Power
• Assay: 98%
• Particle Size: Nlt 95% Pass 80 Mesh
• Storage: Room Temperature
• Shelf Life: 2 Years
• Factory: Yes
• Sample: 20g Free Sample
• Grade: Food Grade
• OEM Service: Available
• Stock: in Stock
• CAS No.: 334-50-9
• Transport Package: Drum
• Specification: 25kg/drum
• Trademark: Comext
• Origin: China
• HS Code: 293090
• Production Capacity: 500mt/Year

Product Description

Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T₄ polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.

Spermidine is an aliphatic polyamine. Spermidine synthase (SPDS) catalyzes its formation from putrescine. It is a precursor to other polyamines, such as spermine and its structural isomer thermospermine.

Spermidine synchronizes an array of biological processes, (such as Ca²⁺, Na⁺, K⁺ -ATPase) thus maintaining membrane potential and controlling intracellular pH and volume. Spermidine regulates biological processes, such as Ca²⁺ influx by glutamatergic N-methyl-D-aspartate receptor (NMDA receptor), which has been associated with nitric oxide synthase (NOS) and cGMP/PKG pathway activation and a decrease of Na⁺,K⁺-ATPase activity in cerebral cortex synaptosomes.

Spermidine is a longevity agent in mammals due to various mechanisms of action, which are just beginning to be understood. Autophagy is the main mechanism at the molecular level, but evidence has been found for other mechanisms, including inflammation reduction, lipid metabolism, and regulation of cell growth, proliferation, and death.

Spermidine also appears to improve cognitive function in early preclinical tests in rodents. The beneficial effects of [Spermidine] appear to depend on autophagy- and likely mitophagy-related processes that culminate in improved mitochondrial capacity, at least in model organisms."

 

Product Name	Spermidine Trihydrochloride		CAS#		334-50-9
Formula	C7H19N3-3HCl		Formula weight		254.63
Production Date	2023-04-11		Batch No.		2023041102
Test Date	2023-04-11		Pack Size		5Kg/Carton
Expiry Date	2 Years		Origin		China
Test Items &Result
Test Items		Specification		Result		MOA
Appearance		White to off-white power		Off-White Powder		Visual
Purity		≥98%		98.66%		GC
Solubility		Soluble in water		Conform		CP2020
Loss on drying		≤1.0%		0.41%		CP2020
Residue on ignition		≤0.2%		0.08%		CP2020
Ethanol(GC)		≤5000ppm		600ppm		GC
heavy metal content
Pb		≤0.1 ppm		Conform		GB5009
Hg		≤0.1 ppm		Conform		GB5009
Cd		≤0.2 ppm		Conform		GB5009
As		≤0.1 ppm		Conform		GB5009
Total microbial count		≤500CFU/g		<10		GB4789
Coliform		≤0.92MPN/g		Conform		GB4789
Mold and yeas		≤50CFU/F		Conform		GB4789
Staphylococcus aureus		0/25g		Conform		GB4789
Salmonella		0/25g		Conform		GB4789
Conclusion		All inspection items are in conformity with the specifications
Storage Condition		Sealed packaging,stored at cool,dry and away from light.